52 articles - From Friday Aug 22 2025 to Friday Aug 29 2025
Guidelines and related publications, position statements, white papers, technical reviews, consensus statements, etc…
| Am J Clin Nutr |
|---|
Associations between intakes of food groups recommended by the Dietary Guidelines for Americans and iron status in subsets of the US population: a cross-sectional study. Adherence to the DGAs supports dietary iron intake but not iron status. Specific food groups were associated with iron status in different analysis subsets, highlighting areas to emphasize to support iron status in certain US demographics. |
| Liver Transpl |
AASLD AST Practice Guideline on Adult Liver Transplantation: Diagnosis and management of Graft-Related complications. While robust clinical trial data provide strong guidance on some aspects of graft management in LT such as machine perfusion and immunosuppression efficacy and safety, a significant component of graft management is derived from retrospective cohort data, extrapolation of data from other solid organ transplants, or expert opinion, including the treatment of antibody-mediated rejection. Finally, further investigation is needed to truly optimize the management of the liver allograft, including the prevention of recurrent alcohol-associated, metabolic dysfunction-associated steatotic and immune-mediated liver diseases. |
meta-analyses and systematic reviews
| Inflamm Bowel Dis |
|---|
Systematic Review With Meta-Analysis: Safety and Effectiveness of Combining Biologics and Small Molecules in Inflammatory Bowel Diseases. High clinical response rates were also seen in Tofa + aTNF (82.7%, 34 TTs), UST + aTNF (82.1%, 63 TTs), and VDZ + UST (82.0%, 71 TTs). Combining biologics and/or small molecules may be effective for IBD patients who fail to achieve remission with monotherapy; however, safety profiles need to be carefully considered prior to implementing these strategies in clinical practice. |
RCT, clinical trials, retrospective studies, etc…
| Am J Clin Nutr |
|---|
Anthropometric Indices for Predicting Incident Cardiovascular Disease : A 13-Year Follow-Up Study in a Japanese population. BRI and WHtR were more significant predictors of incident CVD in Japanese males over 13 years of follow-up than BMI, WC, and ABSI. The identified cutoffs may help improve risk stratification and support early preventive interventions to reduce cardiovascular risk. |
Global metabolite profiling in feces, serum, and urine yields insights into energy balance phenotypes induced by diet-driven microbiome remodeling. These findings lay the foundation for unveiling causal pathways linking diet-microbiota co-metabolism to energy absorption. NCT02939703 |
Habitual Breakfast Skipping and Night Eating Associated with Unfavorable Changes in Lipid Profiles in Chinese Adults: A Longitudinal Analysis. Compared to optimal eating behaviors, these non-optimal eating behaviors were associated with a more rapid increase in triglyceride concentrations and a faster decrease in high-density lipoprotein cholesterol (P-trend < 0.05 for both). Frequent breakfast skipping and night eating were associated with unfavorable longitudinal changes in lipid profiles. |
Novel genetic variants associated with stable isotope-based vitamin B12 bioavailability measurements in healthy Indian adults. These findings provide insights into the genetic determinants of vitamin B12 absorption and homeostasis, emphasizing the potential of genetic markers for personalized nutritional strategies. This is critical for identifying subgroups susceptible to B12 deficiency despite adequate intake, highlighting the need for precision nutrition led by functional measurements in specific populations. |
| Inflamm Bowel Dis |
Early-Life Body Mass Index and Inflammatory Bowel Disease Risk: A Scandinavian Birth Cohort Study. In this Scandinavian birth cohort, 7-8 year-old children with obesity had an increased risk of developing ulcerative colitis later in life. Given the high prevalence of childhood obesity, this observation should be corroborated and possible mechanisms behind the association clarified. |
Identifying Potential Targets for the Interception of Inflammatory Bowel Disease: Toward Precision Prevention. While most evidence to date has focused on CD, we also review preclinical insights relevant to UC. As the field moves toward earlier identification of at-risk individuals, the concept of "precision prevention"-matching interventions to individual risk and biology-may ultimately shift the paradigm of IBD care from treatment to prevention. |
InflammationHypoxia-Inducible Factor Signaling Compensates for Aryl Hydrocarbon Receptor in Maintaining Gut Barrier Integrity. Our findings suggested that high intestinal permeability due to AhR deficiency can be ameliorated by the stabilization of HIFs, indicating a compensatory role in barrier maintenance. This discovery holds promise for advancing therapeutic strategies for patients with gut permeability issues such as inflammatory bowel disease. |
Long-term Outcomes of Patients with Crohn's Disease Treated with Risankizumab. In this real-world cohort with long-term follow-up, risankizumab was generally effective in patients with CD. Penetrating CD was associated with treatment failure, while perianal fistulizing CD and prior exposure to more than 2 biologics were associated with treatment escalation. |
Real-World Experience with Upadacitinib for Pediatric Acute Severe Ulcerative Colitis: An International Multicenter Retrospective Study from the Pediatric IBD Porto Group of ESPGHAN. Twelve patients reported AEs, including two serious AEs of an appendiceal neuroendocrine tumor and cytomegalovirus colitis. Upadacitinib is an effective induction therapy for children and adolescents with ASC after failing anti-TNF. |
Role of lncRNA MGP202 in Modulating B Cell Dynamics and Its Implications in Ulcerative Colitis. These findings highlight MGP202 as a potential diagnostic and therapeutic target for UC, particularly in the context of B cell dynamics. Further investigations are warranted to evaluate clinical applicability and unravel additional mechanisms related to MGP202 modulation of B cell behavior in UC. |
ScreeningLessons from Prediction and Prevention of Type 1 Diabetes. This provided a pathway for regulatory approval by clarifying that therapy was aimed at treating people with disease in contrast to preventing disease in healthy individuals and has helped antibody-positive individuals understand risk. Translating these scientific accomplishments into clinical practice remains challenging, but the availability of an approved therapy to delay T1D onset suggests that such translation is on the horizon for T1D and ultimately for other immune-mediated diseases. |
Sexual Health Concerns and Health Care Experiences of LGBTQ+ Patients with Inflammatory Bowel Disease. One in 4 LGBTQ+ patients listed fear of discrimination as a source of discomfort in these discussions, and a similar proportion expressed uncertainty regarding whether their sexual and/or gender identity negatively impacted their IBD care. Further research and enhanced provider awareness of sexual health challenges related to IBD among LGBTQ+ patients may serve as an important step toward advancing inclusive and culturally sensitive care for this patient population. |
Tissue MicroRNA Expression Signatures as Diagnostic Biomarkers and Predictors of Residual Disease Activity and Relapse in Treatment-Naïve Pediatric Inflammatory Bowel Disease. In this study, we have established tissue miRNA expression signatures with significant diagnostic and prognostic potential for use in PIBD. These findings aid in stratifying disease severity and risk, paving the way for more precise and personalized management of pediatric IBD. |
| J Crohns Colitis |
Assessing intestinal fibrosis using an endoscopic photoacoustic-ultrasound balloon catheter in rabbits and a human subject. Our novel imaging catheter shows reliability in differentiating the changes in molecular components and mechanical properties during the progression of intestinal fibrosis. This catheter-based approach is fully compatible with clinical colonoscopy procedures. |
Comparing standard versus intensified pneumococcal vaccination regimens in patients with inflammatory bowel disease on biologics: a prospective, multicenter, randomized, open-label study. Both regimens were well tolerated, with no differences in safety profiles or IBD relapse rates. Intensified vaccination significantly enhances and sustains immune response over 36 months, particularly benefiting patients with CD on anti-TNF therapy. |
Impact of Type 2 Diabetes on Clinical Outcomes and Advanced Therapy Use in Patients with Crohn's Disease: a Real-World Propensity Score-Matched Analysis. Patients with CD and coexisting T2DM experience a more severe disease course yet appear to be undertreated with advanced therapies. These findings highlight the need for tailored, multidisciplinary management strategies in this high-risk population. |
Impact of advanced therapies on surgical recurrence following second ileocolic resection in Crohn's disease. No statistically significant reduction in third surgery rates were observed in patients receiving prophylactic advanced therapies. This may reflect both the predominantly stricturing disease as indication for redo surgery, which is typically less amenable to medical treatment, and the shorter follow-up in C2. |
Micronutrients are associated with endoscopic postoperative recurrence in Crohn's disease: a multicenter prospective cohort study in North america. A machine-learning model combining nutrient intake and clinical factors enhanced the prediction of ePOR. These findings highlight the importance of postoperative nutritional assessment and suggest dietary interventions may help prevent postoperative recurrence in CD. |
Transmural healing in ulcerative colitis patients improves long-term outcomes compared to endoscopic healing alone. In UC patients TH is associated with lower relapse risk compared to EH alone. These findings imply that IUS is a non-invasive, low-cost alternative to endoscopy for stratifying UC patients for risk of relapse. |
| Liver Transpl |
Coproducing a health advocate intervention for pediatric liver transplant recipients using a human-centered design. Using structured design methodology, we designed a prototype navigator role for pediatric liver transplant care teams. Future studies should test the effectiveness of this navigator role in improving posttransplant outcomes. |
Evaluation of living liver donors identifying as transgender or gender diverse. As the liver transplant community works to expand and standardize the living donor evaluation, it is imperative that we consider the unique risk stratification considerations for this marginalized population. Herein, we review the nuances unique to psychosocial and medical considerations, including gender-affirming hormone therapy and perioperative management, with a focus on creating an inclusive environment. |
HepB-CpG vaccination: An alternate strategy to life long antiviral therapy in patients transplanted for chronic Hepatitis B. Long term protection is sustainable with periodic boosters. New biomarkers for HBV allow earlier detection of underlying viral transcription and may promote better understanding of vaccine failure. |
Tumor burden and frailty: No association in liver transplant candidates with hepatocellular carcinoma. Patients with HCC awaiting liver transplantation, who generally have well-compensated liver disease, may therefore exhibit a distinct frailty profile-driven by non-hepatic comorbidities rather than by liver failure or tumor burden. These findings support the need for HCC-specific frailty research to guide evaluation and management. |
| Pancreas |
Alteration of Apolipoprotein A2 Isoforms is Associated with the Progression of Chronic Pancreatitis. A positive apoA2-i index was associated with CP progression. Further studies are warranted to determine whether it could serve as a surrogate marker for pancreatic exocrine dysfunction. |
Pancreatic and Peripancreatic Neural-Crest Derived Tumors: An Updated Contemporary Single Center Experience. Paragangliomas have malignant potential and should be managed with an oncologic resection. Accurate preoperative diagnosis using EUS-FNA and nuclear imaging is crucial for recommending the appropriate surgical intervention and minimizing surgical morbidity. |
| Pancreatology |
Genetic evidence for the causal impact of immune cells on pancreatic neuroendocrine tumors and the mediating effects of cathepsins. This study provides novel insights into the causal roles of immune cell traits and cathepsins in pNETs progression. The findings highlight potential targets for therapeutic intervention, emphasizing the complex interplay between the immune system and tumor biology in pNETs. |
Plenty of the editorials are available as full text through the publisher website using the provided link
misc publications eg case reports, tools of the trade, images of the month, etc…
| Inflamm Bowel Dis |
|---|
| Liver Transpl |
| Pancreas |
| Pancreatology |
Letters to the editors and authors’ replies
| Pancreas |
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| Pancreatology |